Human-animal chimeras are taking over the barnyard. A year after a research team announced they had created the first animal-human chimera by way of pig embryos containing human cells, they’ve done it again, the Guardian reports. This time it’s sheep embryos with human cells. The goal is to improve the availability and success rates of organ transplants by growing human organs inside animals. “Even today the best matched organs, except if they come from identical twins, don’t last very long because with time the immune system continuously is attacking them,” Dr. Pablo Ross says. According to the Telegraph, Ross’ team grew the embryos inside a sheep for three weeks. He says sheep have a number of advantages over pigs, including that their embryos are easier to produce via IVF. (READ MORE)
Since 2002, the American Association for the Advancement of Science’s (AAAS) statement on human cloning has been the definitive guide for scientists in the U.S. regarding the ethics of human cloning. As Joanne Carney, program director of the AAAS’s Office of Government Relations told Futurism, the association has no plans to revise its statement or change its stance on reproductive cloning in humans in light of recent developments. However, according to Margaret R. McLean, director of bioethics at the Markkula Center for Applied Ethics, that might just be because they don’t yet have the commercial incentive to go against it. If such an incentive were to arise, such as the ability to clone human bodies solely for the purpose of harvesting healthy organs, scientists may start to reconsider the AAAS’s ban on human cloning. “The prospect of creating ‘shell bodies’ to harvest organs would be very promising and might vastly improve human health and welfare,” bioethicist Jacob Appel told Futurism. “The caveat here is that these clones would have to be merely shell bodies. It would be highly unethical to harvest such organs from clones that were actually sentient human beings.” (READ MORE)
EDITOR’S NOTE: In the countdown to the release of the highly anticipated documentary “INHUMAN: THE NEXT AND FINAL PHASE OF MAN IS HERE”(scheduled for release around August 15), SkyWatch TV is running this exclusive online series on transhumanism and the dawn of the Human Hybrid Age.
Synthetic biologists forecast that as computer code is written to create software to augment human capabilities, so too genetic code will be written to create life forms to augment civilization.
—Jerome C. Glenn
Homo sapiens, the first truly free species, is about to decommission natural selection, the force that made us. Soon we must look deep within ourselves and decide what we wish to become.
—Edward Osborne Wilson
Resistance is futile! You will be assimilated!
Not long ago, a writer for Wired magazine named Elizabeth Svoboda contacted me (Tom) to let me know she was writing an article about “research advances using transgenic animals to produce pharmaceutical compounds.” She had come across an editorial by me raising caution about this kind of experimentation and wondered if I might be willing to provide points for her article, elaborating in areas where I saw producing transgenic human-animals as potentially harmful. She stated that most of the scientists she planned to quote were “pretty gung-ho about the practice,” and said she thought it would be important to provide some balance. I thanked her for the invitation and sent a short summary of some, though not all, of the areas where concerns about this science could be raised.
When the article was finally published by Wired, I was surprised that none of my notes had made it into the story. I contacted Elizabeth and asked why, and she replied that they had originally been included in her article, “Pharm Animals Crank Out Drugs,” but in order to create a positive spin on the story, the editors had censored my cautionary notes during the editing process. Elizabeth apologized and said she hoped the experience had not soured me on dealing with the magazine.
“It doesn’t sour me,” I assured her. “I just think the reporting by most agencies is lopsided and missing the opportunity to thoroughly engage such an important issue.” The fact was, Wired magazine deprived the public of balanced treatment on an important subject and concluded instead with a scientist by the name of Marie Cecile Van de Lavoir saying that potential human health benefits from transgenic research “justify tinkering” with nature’s plan. “If a transgenic animal produces a great cancer therapy,” she said, “I won’t hear anyone saying, ‘You shouldn’t do that.’” Van de Lavoir’s comments were undoubtedly in response to some of my observations before they were pulled, because in offering caution, I had specifically used the phrase “tinkering with nature’s plan.” Van de Lavoir’s short-sighted approach, like too many bioethicists engaged in the current debate, is as scary as the science, in our opinion. We wanted to contact her to suggest that she watch the film I Am Legend starring Will Smith, which opens appropriately enough with a scientist announcing the cure to cancer using a genetically engineered vaccine that blends animal and human genetics. If you’ve seen the film, you know the “cure” results in a human form of rabies that wipes out most life on earth—a real possibility, given the scenario.
Because any attempt at covering each potential Grin-tech, catastrophic, I-Am-Legend possibility in the upcoming documentary INHUMAN would be impractical, and that film in particular focuses on the human-enhancement era dawning now, we summarize below a few of the most important areas in which conservatives, bioethicists, regulators, and especially Christians could become informed and involved in the public dialogue over the potential benefits and threats represented by these emerging fields of science:
GENETICALLY MODIFIED FOOD
Besides potential problems with transgenic animals, we have cited laboratory results in the past that were first reported by Dr. árpád Pusztai, repeat verified by scientist Irina Ermakova, and later substantiated by the International Journal of Biological Sciences that showed genetically modified (gm) food had surprisingly ill effects on the health of test rats, including the deterioration of every animal organ, atrophied livers, altered cells, testicular damage, altered sperm counts, shortened life spans, and cancer development. The laboratory findings led to the biotech industry suppressing the data and an eight-year court battle with monster corporations that did not want these results made public. Over the last year, the silenced information has been in the news again as Greenpeace activists published evidence from the Russian trials verifying the ramifications of the negative health issues related to genetically modified foods. The wider ramifications from these and similar controlled experiments suggest that as current technology inserts pesticides, insect genes, animal dna, and other modified organisms directly into crops, the threat of hybrid viruses, prion contamination and new disease strains—which man can neither anticipate or prepare for—may arise. The prospects of this having an impact on mammalian health is almost certain to be a “when,” not “if,” concern, because, as Momma always said, “you are what you eat,” and the fact that the food you consumed this week most likely contained genetically modified ingredients is a current reality. For example, a large portion of the soybean, corn, cottonseed, and canola in today’s human food supply and sold in most developed countries including the United States now has genes spliced in from foreign species—including bacteria and viruses—in its genetic makeup. These genetically modified organisms (gmos) have not only been linked to sickness, sterility, allergies, and even death among animals, but the Institute for Responsible Technology (irt) documents how the functioning genetically modified genes from these foods linger inside the human body, which could be future-catastrophic. “The only published human feeding experiment verified that genetic material inserted into gm soy transfers into the dna of intestinal bacteria and continues to function,” irt published. “This means that long after we stop eating gm foods, we may still have their gm proteins produced continuously inside us.”[i]
Among other things, irt says this means that: 1) If the antibiotic gene inserted into most gm crops were to transfer, it could create super diseases resistant to antibiotics; 2) If the gene that creates Bt toxin in gm corn were to transfer, it might turn our intestinal flora into living pesticide factories; and 3) Animal studies show that dna in food can travel into organs throughout the body, even into the fetus. Add to this the growing secrecy over the use of nanoparticles (eighty-four food-related uses are already on the market and in numerous consumer products such as sunscreens and cosmetics), which as a result of their size behave fundamentally different than other particles, and the possibility of health-related complications increases exponentially. Due to the large corporations (that stand to make billions of dollars from these products) having co-opted the fda into not requiring food labeling or package warnings on gmo foods and health products, you and I are now the biggest lab rats of all time in a “wait-and-see” experiment that will, feasibly within the decade, illustrate whether Pusztai and Ermakova’s rodent findings apply to us and our children.
Synthetic biology is one of the newest areas of biological research that seeks to design new forms of life and biological functions not found in nature. The concept began emerging in 1974, when Polish geneticist Waclaw Szybalski speculated about how scientists and engineers would soon enter “the synthetic biology phase of research in our field. We will then devise new control elements and add these new modules to the existing genomes or build up wholly new genomes. This would be a field with the unlimited expansion [of] building new¼‘synthetic’ organisms, like a ‘new better mouse.’”[ii] Following Szybalski’s speculation, the field of synthetic biology reached its first major milestone in 2010 with the announcement that researchers at the J. Craig Venter Institute (jcvi) had created an entirely new form of life nicknamed “Synthia” by inserting artificial genetic material, which had been chemically synthesized, into cells that were then able to grow. The jcvi Web site explains:
Genomic science has greatly enhanced our understanding of the biological world. It is enabling researchers to “read” the genetic code of organisms from all branches of life by sequencing the four letters that make up dna. Sequencing genomes has now become routine, giving rise to thousands of genomes in the public databases. In essence, scientists are digitizing biology by converting the A, C, T, and G’s of the chemical makeup of dna into 1’s and 0’s in a computer. But can one reverse the process and start with 1’s and 0’s in a computer to define the characteristics of a living cell? We set out to answer this question [and] now, this scientific team headed by Drs. Craig Venter, Hamilton Smith, and Clyde Hutchison have achieved the final step in their quest to create the first¼synthetic genome [which] has been “booted up” in a cell to create the first cell controlled completely by a synthetic genome.[iii]
The jcvi site goes on to explain how the ability to routinely write the software of life will usher in a new era in science, and with it, unnatural “living” products like Szybalski’s “new better mouse.” Better mice, dogs, horses, cows, or humans that grow from this science will be unlike any of the versions God made. In fact, researchers at the University of Copenhagen may look at what Venter has accomplished as amateur hour compared to their posthuman plans. They’re working on a third Peptide Nucleic Acid (pna) strand—a synthetic hybrid of protein and dna—to upgrade humanity’s two existing dna strands from double helix to triple. In so doing, these scientists “dream of synthesizing life that is utterly alien to this world—both to better understand the minimum components required for life (as part of the quest to uncover the essence of life and how life originated on earth) and, frankly, to see if they can do it. That is, they hope to put together a novel combination of molecules that can self-organize, metabolize (make use of an energy source), grow, reproduce and evolve.”[iv] Our good friend and host of SkyWatch TV, Gary Stearman and other biblical scholars are raising red flags over Synthia technology, warning that any biotech life application leading to modification of the human genotype for “improved” humans will be an inconceivable affront to God and could result in divine repercussions.
PATENTING NEW LIFE-FORMS
Questions are evolving now over “patenting” of transgenic seeds, animals, plants, and synthetic life-forms by large corporations, which at a minimum has already begun to impact the economy of rural workers and farmers through such products as Monsanto’s “terminator” seeds. Patenting of human genes will escalate these issues, as best-selling author Michael Crichton pointed out a while back in a piece for the New York Times titled, “Gene Patents Aren’t Benign and Never Will Be,” in which he claimed that people could die in the future from not being able to afford medical treatment as a result of medicines owned by patent holders of specific genes related to the genetic makeup of those persons. Former special counsel for President Richard Nixon, Charles Colson, added, “The patenting of genes and other human tissue has already begun to turn human nature into property. The misuse of genetic information will enable insurers and employers to exercise the ultimate form of discrimination. Meanwhile, advances in nanotechnology and cybernetics threaten to ‘enhance’ and one day perhaps rival or replace human nature itself—in what some thinkers are already calling ‘transhumanism.’”[v]
(article continues below video)
WATCH THE INHUMAN TRAILER
Animal-rights activists have raised similar questions having to do with the ethics of altering animals in ways that could be demeaning to them—for instance, creating zombielike creatures that grow in feeder labs and gaze off into space from birth until death. Militarized animals that behave in unnatural, unpredictable ways. Humanized animals that become “self-aware,” or animals that produce human sperm and eggs, which then are used for in vitro fertilization to produce a human child. Who would the parents be? A pair of mice?
The prospect of human cloning was raised in the nineties immediately after the creation of the much-celebrated “Dolly,” a female domestic sheep clone. Dolly was the first mammal to be cloned using “somatic cell nuclear transfer,” which involves removing the dna from an unfertilized egg and replacing the nucleus of it with the dna that is to be cloned. Today, a version of this science is common practice in genetics engineering labs worldwide, where “therapeutic cloning” of human and human-animal embryos is employed for stem-cell harvesting (the stem cells, in turn, are used to generate virtually any type of specialized cell in the human body). This type of cloning was in the news not long ago when it emerged from William J. Clinton Presidential Center documents that member of the Supreme Court, Elena Kagan, had opposed during the Clinton White House any effort by Congress to prevent humans from being cloned specifically for experimental purposes, then killed. A second form of human cloning is called “reproductive cloning” and is the technology that could be used to create a person who is genetically identical with a current or previously existing human. While Dolly was created by this type of cloning technology, the American Medical Association and the American Association for the Advancement of Science have raised caution on using this approach to create human clones, at least at this stage. Government bodies including the U.S. Congress have considered legislation to ban mature human cloning, and though a few states have implemented restrictions, contrary to public perception and except where institutions receive federal funding, no federal laws exist at this time in the United States to prohibit the cloning of humans. The United Nations, the European Union, and Australia likewise considered and failed to approve a comprehensive ban on human cloning technology, leaving the door open to perfect the science should society, government, or the military come to believe that duplicate or replacement humans hold intrinsic value.
REDEFINING HUMANS AND HUMAN RIGHTS
Where biotechnology is ultimately headed includes not only redefining what it means to be human, but redefining subsequent human rights as well. For instance, Dr. James Hughes wants transgenic chimps and great apes uplifted genetically so that they achieve “personhood.” The underlying goal behind this theory would be to establish that basic cognitive aptitude should equal “personhood” and that this “cognitive standard” and not “human-ness” should be the key to constitutional protections and privileges. Among other things, this would lead to nonhuman “persons” and “nonperson” humans, unhinging the existing argument behind intrinsic sanctity of human life and paving the way for such things as harvesting organs from people like Terry Schiavo whenever the loss of cognitive ability equals the dispossession of “personhood.” These would be the first victims of transhumanism, according to Prof. Francis Fukuyama, concerning who does or does not qualify as fully human and is thus represented by the founding concept that “all men are created equal.” Most would argue that any human fits this bill, but women and blacks were not included in these rights in 1776 when Thomas Jefferson wrote the Declaration of Independence. So who is to say what protections can be automatically assumed in an age when human biology is altered and when personhood theory challenges what bioethicists like Wesley J. Smith champion as “human exceptionalism”: the idea that human beings carry special moral status in nature and special rights, such as the right to life, plus unique responsibilities, such as stewardship of the environment. Some, but not all, believers in human exceptionalism arrive at this concept from a biblical worldview based on Genesis 1:26, which says, “And God said, ‘Let us make man in our image, after our likeness: and let them have dominion over the fish of the sea, and over the fowl of the air, and over the cattle, and over all the earth, and over every creeping thing that creepeth upon the earth.’”
NANOTECHNOLOGY and CYBERNETICS
As discussed in the upcoming documentary, technology to merge human brains with machines is progressing at a fantastic rate. Nanotechnology—the science of engineering materials or devices on an atomic and molecular scale between 1 to 100 nanometers (a nanometer is one billionth of a meter) in size—is poised to take the development between brain-machine interfaces and cybernetic devices to a whole new adaptive level for human modification. This will happen because, as Dr. C. Christopher Hook points out:
Engineering or manipulating matter and life at nanometer scale [foresees] that the structures of our bodies and our current tools could be significantly altered. In recent years, many governments around the world, including the United States with its National Nanotechnology Initiative, and scores of academic centers and corporations have committed increasing support for developing nanotechnology programs. The military, which has a significant interest in nanotechnology, has created the Center for Soldier Nanotechnologies (csn) [which is] interested in the use of such technology to help create the seamless interface of electronic devices with the human nervous system, engineering the cyborg soldier.[vi]
In the early part of the twentieth century, the study and practice of selective human breeding known as eugenics sought to counter dysgenic aspects within the human gene pool and to improve overall human “genetic qualities.” Researchers in the United States, Britain, Canada, and Germany (where, under Adolf Hitler, eugenics operated under the banner of “racial hygiene” and allowed Josef Mengele, Otmar von Verschuer, and others to perform horrific experiments on live human beings in concentration camps to test their genetic theories) were interested in weeding out “inferior” human bloodlines and used studies to insinuate heritability between certain families and illnesses such as schizophrenia, blindness, deafness, dwarfism, bipolar disorder, and depression. Their published reports fueled the eugenics movement to develop state laws in the 1800s and 1900s that forcefully sterilized persons considered unhealthy or mentally ill in order to prevent them from “passing on” their genetic inferiority to future generations. Such laws were not abolished in the U.S. until the mid-twentieth century, leading to more than sixty thousand sterilized Americans in the meantime. Between 1934 and 1937, the Nazis likewise sterilized an estimated four hundred thousand people they deemed of inferior genetic stock while also setting forth to selectively exterminate the Jews as “genetic aberrations” under the same program. Transhumanist goals of using biotechnology, nanotechnology, mind-interfacing, and related sciences to create a superior man and thus classifications of persons—the enhanced and the unenhanced—opens the door for a new form of eugenics and social Darwinism.
GERM-LINE GENETIC ENGINEERING
Germ-line genetic engineering has been in the news recently due to development of “Crispr technology” – which is a more precise way of editing DNA than anything that has come before and is being hailed as the start of “a new era of genetics” involving a wide-range of experiments in thousands of laboratories currently that reopens questions about genetically modifying people. Germline gene editing has the potential to actually achieve the goals of the early eugenics movement (which sought to create superior humans via improving genetics through selective breeding) through genetically modifying human genes in very early embryos, sperm, and eggs, which then becomes heritable. As a result, germ-line engineering is considered by some conservative bioethicists to be the most dangerous of human-enhancement technology, as it has the power to truly reassemble the very nature of humanity into posthuman, altering an embryo’s every cell and leading to inheritable modifications extending to all succeeding generations. Debate over germ-line engineering is therefore most critical, because as changes to “downline” genetic offspring are set in motion, the nature and physical makeup of mankind will be altered with no hope of reversal, thereby permanently reshaping humanity’s future. A respected proponent of germ-line technology is Dr. Gregory Stock, who, like cyborgist Kevin Warwick, departs from Kurzweil’s version of Humans 2.0 first arriving as a result of computer Singularity. Stock believes man can choose to transcend existing biological limitations in the nearer future (at or before computers reach strong artificial intelligence) through germ-line engineering. If we can make better humans by adding new genes to their dna, he asks, why shouldn’t we? “We have spent billions to unravel our biology, not out of idle curiosity, but in the hope of bettering our lives. We are not about to turn away from this,” he says, before admitting elsewhere that this could lead to “clusters of genetically enhanced superhumans who will dominate if not enslave us.”[vii] The titles to Stock’s books speak for themselves concerning what germ-line engineering would do to the human race. The name of one is Redesigning Humans: Our Inevitable Genetic Future and another is Metaman: The Merging of Humans and Machines into a Global Superorganism.
Besides the short list above, additional areas of concern where readers may wish to become well advised on the pros and cons of enhancement technology include immortalism, postgenderism, augmented reality, cryonics, designer babies, neurohacking, mind uploading, neural implants, xenotransplantation, reprogenetics, rejuvenation, radical life extension, and more.
TO BE CONTINUED…
[i]Institute for Responsible Technology, http://www.responsibletechnology.org/GMFree/Home/index.cfm.
[ii] Waclaw Szybalski, In Vivo and in Vitro Initiation of Transcription, 405. In A. Kohn and A. Shatkay (eds.), Control of Gene Expression, 23–24, and Discussion 404–405 (Szybalski’s concept of Synthetic Biology), 411–412, 415–417 (New York: Plenum, 1974).
[iii] “First Self-Replicating Synthetic Bacterial Cell,” J. Craig Venter Institute, http://www.jcvi.org/cms/research/projects/first-self-replicating-synthetic-bacterial-cell.
[iv] Peter E. Nielsen, “Triple Helix: Designing a New Molecule of Life,” Scientific American (12/08) http://www.scientificamerican.com/article.cfm?id=triple-helix-designing-a-new-molecule&ec=su_triplehelix.
[v] Charles W. Colson, Human Dignity in the Biotech Century (Downers Grove, IL: InterVarsity, 2004) 8.
[vi] C. Christopher Hook, Human Dignity in the Biotech Century (Downers Grove, IL: InterVarsity, 2004) 80–81.